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September 19, 2012

What's your Medical Diagnosis? 27y M, Fatigue, Weakness, Weight Loss

The Isabel diagnosis tool touts an extensive database of conditions for differential diagnosis support, and we often will test its accuracy with real patient cases from the New England Journal of Medicine.

About the Isabel Diagnosis Challenge

The New England Journal of Medicine (NEJM) publishes interesting presentations of common diseases and unusual cases in the Clinical pathology Conference (CPC) series. These cases are educational and can pose diagnostic challenges even to the expert physicians at the Massachusetts General Hospital.

New England Journal of MedicineUsing the clinical features of these cases you can evaluate your own diagnostic skills and compare your diagnostic performance to that of the physicians at MGH. If you are registered with Isabel as a client or have a free-trial subscription, you can use the diagnosis reminder system and run through some scenarios to get a list of likely suspects. Clicking on a diagnosis will take you through to various knowledge sources and links available from within Isabel.

Today's Case: 2012: #21

Demographic: Male, 27 years, North America
Clinical features:

  • profound weight loss
  • weakness
  • loss of libido
  • pneumomediastinum
  • hypotension
  • fatigue
  • constipation
  • cachexia
  • bitemporal wasting
  • depressed affect
  • poor dentition
  • peripheral neuropathy

STOP! Before you continue, construct your own: Final diagnosis

Final Diagnosis of the case according to NEJM: Eating disorder not otherwise specified (EDNOS)
Was the final diagnosis given by Isabel: Yes, Eating disorder under Psychology


Case 21 resized 600















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