Isabel DDx Companion with ChatGPT Integration - to help you diagnose even faster

At Isabel Healthcare, we’ve always been driven by one goal: to make clinical reasoning faster, smarter, and safer for every clinician.

Now, with our latest update to Isabel DDx Companion, we’re taking that mission to the next level with the addition of ChatGPT — built to enhance diagnostic decision-making without compromising accuracy or trust.

Why We Built It

Artificial intelligence has shown enormous promise in medicine, but not all AI is created equally. Many general-purpose LLMs are powerful but prone to hallucinations and variability — not acceptable when patient care is on the line.

That’s why we took a different approach: combining the validated Isabel DDx engine — trusted by clinicians for the past 25 years (it is our silver anniversary this year) with the contextual power of ChatGPT to deliver explanations and comparisons that truly support clinical reasoning even faster.

“The Isabel DDx Companion LLM doesn’t create a differential diagnosis on its own — it begins with Isabel’s proven results and enhances them,” explains the Isabel Healthcare team. “This approach ensures we preserve the accuracy and reliability clinicians trust if Isabel, while integrating the interpretive power of modern AI to analyze and compare the results in more detail.”

What’s New for Isabel DDX Companion Subscribers

After you have selected your query using the patient’s age, sex at birth, travel history and presenting symptoms, the Isabel DDx Companion generates its trusted differential diagnosis for you to review. You can then select between 2 and 5 diagnoses from Isabel’s list to compare and help you quickly focus on the most likely ones.

These functions are:

Isabel AI Diagnosis Explained – provides concise ChatGPT - powered explanations on what the disease is.

Isabel AI Diagnosis Compare – Allows you to view key variables between symptoms, investigations to consider, treatments, prognosis side by side to help you quickly narrow your differential and tailor your workup of your patient.

Trusted Foundations: Every result remains anchored in Isabel’s validated DDx engine, minimizing the risks of misinformation or bias.

Evidenced Based Resources: The Isabel Knowledge Window accessible from each diagnosis allows you to dig deeper with key evidenced based texts from Merck Manual and PubMed directly.

Unlimited Device Access: Use Isabel on any desktop or tablet. (please note: the ChatGPT features are currently on desktop only and available in English)

Isabel DDx Companion

Isabel AI Diagnosis Explained

Isabel AI Diagnosis Compare

Here’s what you can expect:

Institutional Subscribers 

The Isabel DDx Companion with the ChatGPT integration is available as an upgrade for current institutional users.
👉 Contact us to schedule a demo and see the new features in action. 

Individual Subscribers

Many clinicians adopt Isabel ahead of their institutions, so we continue to offer flexible individual subscriptions including our new premium subscription with the ChatGPT integration.

• Standard Plan – $149/year (€139 incl. VAT)

• Premium Plan – $199/year (€179 incl. VAT), including full access to the new ChatGPT integration (desktop only)

👉 View individual plans and subscribe

Why It Matters

The Isabel DDX Companion ChatGPT integration brings a new dimension to Isabel’s diagnostic process: it doesn’t just list a possible differential diagnosis — it enhances your clinical reasoning and helps you think through potential causes and narrow your differential.

By surfacing key differentiators and clinical nuances, Isabel’s new AI layer supports reflective practice and promotes deeper understanding — whether you’re confirming a rare diagnosis or teaching diagnostic reasoning.

Try Isabel DDx Companion with ChatGPT Today

Experience the next generation of clinical reasoning support.
Start your free 30-day trial and discover how the new Isabel DDx Companion with ChatGPT can help you reason faster, explain better, and diagnose with greater confidence.

👉 Start your free trial today
👉 Or book a demo for your organization.