The Isabel diagnosis tool touts an extensive database of conditions for differential diagnosis support, and we often will test its accuracy with real patient cases from the New England Journal of Medicine.
The New England Journal of Medicine (NEJM) publishes interesting presentations of common diseases and unusual cases in the Clinical pathology Conference (CPC) series. These cases are educational and can pose diagnostic challenges even to the expert physicians at the Massachusetts General Hospital.
Case 2012:#25
Demographic: Male, 15 years, North America
Clinical features:
STOP! Before you read further you might want to construct your own complete differential diagnosis and final diagnosis.
In the following section you will find: The differential diagnosis constructed by the MGH panel and whether Isabel suggested the final diagnosis.
Differential Diagnoses considered by the MGH panel: Inflammatory bowel disease
Final Diagnosis of the case according to NEJM:
Adenomatous polyp with focal high grade dysplasia. Postobstructive acute appendicitis and periappendicitis.
Differential Diagnoses of the case as given by Isabel: Inflammatory bowel disease in Gastro
Was the final diagnosis given by Isabel: Yes, (i) Cecal polyp in Gastro (ii) Appendicitis in Gastro