--- title: What's your Medical Diagnosis? Newborn with respiratory failure description: Test your medical diagnosis skills with NEJM cases and compare your diagnosis with Isabel diagnosis differential list. image: https://info.isabelhealthcare.com/hs-fs/file-17422300-jpg/images/images-1-resized-600.jpg --- August 13, 2012 # What's your Medical Diagnosis? Newborn with respiratory failure   The [Isabel diagnosis ](https://info.isabelhealthcare.com/blog/bid/130115/demo-request/)tool touts an extensive database of conditions for differential diagnosis support, and we often will test its accuracy with real patient cases from the New England Journal of Medicine. ## About the Isabel Diagnosis Challenge The [**New England Journal of Medicine**](http://content.nejm.org/) (NEJM) publishes interesting presentations of common diseases and unusual cases in the Clinical pathology Conference (CPC) series. These cases are educational and can pose diagnostic challenges even to the expert physicians at the Massachusetts General Hospital. [![New England Journal of Medicine](https://info.isabelhealthcare.com/hs-fs/file-17422300-jpg/images/images-1-resized-600.jpg?width=48&height=48&name=images-1-resized-600.jpg)](http://nejm.org/)Using the clinical features of these cases you can evaluate your own diagnostic skills and compare your diagnostic performance to that of the physicians at MGH. If you are registered with Isabel as a client or have a free-trial subscription, you can use the diagnosis reminder system and run through some scenarios to get a list of likely suspects. Clicking on a diagnosis will take you through to various knowledge sources and links available from within Isabel. ## Today's Case NEJM 12:19 --  **Premature newborn boy with respiratory failure.** **Demographic**: Male, neonate, North America **Clinical features:** - respiratory distress - respiratory acidosis - skin mottling - irritability - lethargy - fever - cardiomegaly **STOP! Before you read further, create your own differential diagnosis.** **Final Diagnosis of the case according to NEJM and Isabel:** Neonatal herpes simplex virus infection, involving the lungs, liver and adrenal glands, with sepsis **Was the final diagnosis given by the Isabel system: Yes**, Neonatal herpes simplex virus infection under Herpes simplex virus [![NEJM Herpes Case 19](https://info.isabelhealthcare.com/hs-fs/file-17417926-gif/images/case_19-resized-600.gif)](https://info.isabelhealthcare.com/whitepaper/)                               [![Download White Paper](https://no-cache.hubspot.com/cta/default/133692/b16a24c1-2685-4b14-8ab2-be29afd4507f.png)](https://cta-redirect.hubspot.com/cta/redirect/133692/b16a24c1-2685-4b14-8ab2-be29afd4507f) [![Click me](https://no-cache.hubspot.com/cta/default/133692/20c6429f-5f8d-43db-bb3c-6bb4bb0c7191.png)](https://cta-redirect.hubspot.com/cta/redirect/133692/20c6429f-5f8d-43db-bb3c-6bb4bb0c7191) [![Share on Facebook](https://static.hubspot.com/final/img/common/icons/social/facebook-24x24.png)](http://www.facebook.com/share.php?u=https%3A%2F%2Finfo.isabelhealthcare.com%2Fblog%2Fmedical-diagnosis-newborn-respiratory-failure%3Futm_medium%3Dsocial%26utm_source%3Dfacebook) [![Share on LinkedIn](https://static.hubspot.com/final/img/common/icons/social/linkedin-24x24.png)](http://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Finfo.isabelhealthcare.com%2Fblog%2Fmedical-diagnosis-newborn-respiratory-failure%3Futm_medium%3Dsocial%26utm_source%3Dlinkedin) [![Share on Twitter](https://static.hubspot.com/final/img/common/icons/social/twitter-24x24.png)](https://twitter.com/intent/tweet?original_referer=https%3A%2F%2Finfo.isabelhealthcare.com%2Fblog%2Fmedical-diagnosis-newborn-respiratory-failure%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&url=https%3A%2F%2Finfo.isabelhealthcare.com%2Fblog%2Fmedical-diagnosis-newborn-respiratory-failure%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&source=tweetbutton&text=What%27s%20your%20Medical%20Diagnosis%3F%20Newborn%20with%20respiratory%20failure) ### Subscribe Here! 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